Summary
Full time, onsite, #LI-onsite
Within our Oncology and Radioligand Therapy labs we have bold objectives to transform the lives of millions of people affected by cancer. The Oncology Translational Research (OTR) Department at Novartis Biomedical Research is a global, laboratory-based research group, supporting the development of novel therapeutics in the Novartis Biomedical Research Oncology Disease Area.
About the Role
Within OTR, the Oncology Pathology and Biomarkers (OPB) group uses tissue-based, cell-based and soluble protein assays to understand target epidemiology and biology, mechanisms of action of drugs, and response/resistance biomarkers, ranging from early stages of target identification through Phase 3 clinical trials.
OPB is seeking a motivated and curious PhD qualified scientist to design and conduct imaging-based experiments for developing clinical biomarker strategies that advance Novartis Oncology drug candidates. The candidate will partner across the full range of Oncology programs (radioligand therapeutics (RLT), small molecules and biotherapeutics) with a special focus on the effects of RLT on preclinical models and human tissues. This role will involve correlating immunohistochemistry and other imaging techniques with radioligand imaging results to answer key questions related to these therapies. The ideal candidate is passionate about tissue-based biomarker assay development (e.g., IHC, ISH, and FIHC), has a background in imaging, and possesses a keen interest in innovative experimental design.
Key responsibilities:
Design and conduct experiments and procedures requiring scientific and technical knowledge of immunohistochemistry, immunofluorescence, and radioligand imaging
Devise new techniques around tissue-based biomarkers to advance drug development and early discovery programs
Conduct in-depth image analysis of whole slide images using established platforms.
Provide complex data analysis: report experimental hypotheses, experimental details, summation of raw data, graphs and statistical analysis
Supervise the development of multiplex IHC, FIHC and ISH assays to support clinical trials
Mentor and train direct or matrixed reports
Interface with other line functions, researchers and key stakeholders within and outside the organization
Stay updated on the latest developments and trends in the field of Oncology and Radioligand Therapy
Present data at internal and external meetings
Champion external publications and presentations
Deliver high‐quality data to impact drug discovery and projects in clinical development
Role Requirements:
PhD and ideally 2 yrs + postdoctoral/industry experience in Oncology, the Biological Sciences or a related field
Must have experience developing singleplex and multiplex immunohistochemistry and immunofluorescence tissue-based assays
Proven experience with advanced image analysis using various software tools, including HALO
Experience working with cross-functional teams and demonstrated ability to independently drive projects in a matrixed environment
Background in radioligand development and autoradiography is a plus
*Restrictions on flexible working may apply and will be discussed during interview if applicable
Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network
Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards
TEst Hello
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network
Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.